Test Included:
Hepatitis A Immunoglobulin
Test Sample(s) Required:
Blood
How does a test At Home work?
We will send arrange for a nurse to come and collect a sample from you as soon as possible, likely within the next couple of days.
Recommended Test Window Period:
28 days after exposure
Test turnaround time
Between 2-5 working days
Understanding the Difference Between Acute and Chronic Hepatitis A Tests
Hepatitis A is a highly contagious liver infection caused by the Hepatitis A virus (HAV). It primarily spreads through ingestion of contaminated food or water, or through direct contact with an infectious person. The infection can range from a mild illness lasting a few weeks to a severe illness lasting several months. Importantly, unlike hepatitis B and C, hepatitis A does not cause chronic liver disease and is typically self-limiting, meaning it resolves on its own without causing long-term liver damage. However, distinguishing between acute and chronic conditions is crucial for understanding hepatitis A testing.
Acute Hepatitis A Testing
Acute hepatitis A is diagnosed primarily through the detection of IgM antibodies to hepatitis A virus in the blood. IgM antibodies are the first antibodies produced by the immune system when a new infection occurs. They are detectable within a few days to two weeks after the initial HAV infection and can persist for up to 6 months. The presence of IgM antibodies indicates an active, recent HAV infection and can help in diagnosing symptomatic cases of hepatitis A. The test used is called the IgM anti-HAV test.
When is it used?
This test is typically ordered when symptoms such as jaundice (yellowing of the skin and eyes), severe stomach pains, nausea, and diarrhea are present, especially if the person has a history of exposure to HAV or belongs to an area with high HAV incidence.
Chronic Hepatitis A Testing
It is important to clarify that hepatitis A does not lead to a chronic infection. Unlike hepatitis B and C, where the virus can remain in the body for long periods (leading to chronic hepatitis), hepatitis A virus is cleared from the body once the acute phase is over. Therefore, there is no test for chronic hepatitis A because the condition does not exist.
However, a test for IgG antibodies to hepatitis A can be performed to determine past exposure and immunity to the virus. IgG antibodies are produced later and replace IgM antibodies as the infection resolves. They remain in the body for life, providing protection against future infections.
When is it used?
This test is generally used to determine if a person has immunity from a previous infection or from vaccination. It is useful in epidemiological surveys and for checking immunity in populations at risk of hepatitis A exposure.
Key Differences Between Acute and Chronic Test
Purpose of Test:
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IgM anti-HAV test: Used to diagnose acute hepatitis A infection.
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IgG anti-HAV test: Used to determine past infection and immunity.
Implication of Results:
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Positive IgM anti-HAV test: Indicates recent infection, potentially active disease.
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Positive IgG anti-HAV test: Indicates past infection or successful vaccination; no active disease.
Duration of Antibody Presence:
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IgM antibodies: Appear early after infection and are short-lived (up to 6 months).
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IgG antibodies: Appear later and are long-lasting, typically lifelong.